MESOHEAL BIO

Featuring ACAPLEX™, a proprietary complex of KORU-ACA01 peptide and bio-identical Type III collagen, it helps promote natural collagen production, strengthen skin structure, and improve firmness, elasticity, and resilience while reducing the appearance of fine lines and wrinkles.

Formulated with 1.5% non-crosslinked hyaluronic acid, including medium- and high-molecular-weight fractions, it delivers deep hydration and lasting moisture retention. MESOHEAL® BIO helps improve skin texture, smoothness, radiance, and overall skin quality, making it an ideal option for non-surgical anti-aging and skin revitalization treatments.

Indications for Mesoheal Bio:

• Sagging skin
• Fine lines and wrinkles
• Compromised skin barrier
• Dehydrated skin
• Textured or rough skin
• Premature aging signs
• Fragile skin

Benefits Mesoheal Bio:

• Skin renewal
• Anti-aging effect
• Long-lasting hydration
• Reduced wrinkles
• Enhanced skin elasticity

Mechanism of Action:

• Face
• Neck
• Décolleté
• Back of Hands
• Various body areas

Active ingredients:

• KORU-ACA01 peptide
• Bio-Identical Type III Collagen
• 1.5% Dual Molecular Weight Hyaluronic Acid
• ACAPLEX™ Core Components

What is ACAPLEX?

ACAPLEX™ is a patented regenerative technology that combines the KORU-ACA01 peptide with Bio-identical Type III Collagen to help reinforce, protect, and stabilize the extracellular matrix (ECM). This advanced dual-component system is designed to address one of the key causes of skin aging—ECM degradation and loss of structural support.

By promoting ECM regeneration and inhibiting enzymatic breakdown, ACAPLEX™ supports collagen synthesis, improves skin firmness and resilience, and helps maintain long-term structural integrity. The result is stronger, healthier-looking skin with improved elasticity, texture, and overall skin quality.

KORU-ACA01 Peptide Technology

KORU-ACA01 is a proprietary bioengineered peptide developed by Koru Pharma’s R&D Institute. It mimics the signaling function of GH2, playing an important role in maintaining extracellular matrix (ECM) homeostasis and supporting the skin’s structural integrity.

Key Mechanisms of Action

1. Supports ECM Regeneration

KORU-ACA01 promotes the production of essential extracellular matrix proteins, including procollagen, helping restore the skin’s natural support framework. This contributes to:

• Enhanced tissue renewal
• Improved dermal strength
• More uniform and resilient skin structure

2. Helps Protect Against ECM Degradation

The peptide helps inhibit enzymes associated with the breakdown of collagen and elastin, including collagenase, elastase, and MMP-1. By reducing enzymatic degradation, KORU-ACA01 helps preserve collagen and elastin, helping maintain skin firmness and elasticity.

3. Promotes Long-Term Structural Stability

Through its dual action of supporting ECM protein synthesis while limiting ECM degradation, KORU-ACA01 helps reinforce:

• Skin elasticity
• Mechanical resilience
• Long-term dermal integrity
• Scientific Evaluation
• Skin Compatibility

In vitro testing with HS68 human dermal fibroblasts showed no cytotoxicity across the tested concentrations, indicating excellent skin compatibility and supporting its use in aesthetic and dermatological applications.

Procollagen Support

Laboratory studies showed KORU-ACA01 significantly increased procollagen production, demonstrating strong potential to support collagen synthesis and dermal reinforcement.

Enzyme Inhibition

Research also demonstrated KORU-ACA01’s ability to inhibit collagenase, elastase, and MMP-1 activity, helping protect the extracellular matrix from degradation and supporting healthier, more resilient skin.

Bio-identical Type III Collagen

Bio-identical Type III Collagen is engineered to closely resemble naturally occurring human Type III collagen, a key component of youthful, healthy skin. As Type III collagen declines with age, skin can lose elasticity, firmness, and structural support.

By integrating within the extracellular matrix, Bio-identical Type III Collagen helps support:

• Dermal structural reinforcement
• Cellular adhesion and communication
• Skin repair and regeneration processes
• Improved elasticity and firmness

Together, KORU-ACA01 peptide and Bio-identical Type III Collagen form ACAPLEX™, a patented technology designed to support ECM regeneration, protect against structural degradation, and promote healthier, more resilient skin.

Package:
1 box / 5 vials x 5mL